Phase Variation of NadA in Invasive Neisseria meningitidis Isolates Impacts on Coverage Estimates for 4C-MenB, a MenB Vaccine-Reference-Cited by-同舟云学术

Phase Variation of NadA in Invasive Neisseria meningitidis Isolates Impacts on Coverage Estimates for 4C-MenB, a MenB Vaccine

Published:2018-09 Issue:9 Volume:56 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Green Luke R.¹^ORCID,Lucidarme Jay²,Dave Neelam¹,Chan Hannah³,Clark Stephen²,Borrow Ray²,Bayliss Christopher D.¹^ORCID

Affiliation:

1. Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom

2. Meningococcal Reference Unit, Public Health England, Manchester Royal Infirmary, Manchester, United Kingdom

3. National Institute for Biological Standards and Control, Potters Bar, United Kingdom

Abstract

A recombinant NadA protein is one of the four major protective antigens of 4C-MenB (Bexsero), a vaccine developed for serogroup B Neisseria meningitidis (MenB). The meningococcal antigen typing system (MATS) is utilized as a high-throughput assay for assessing the invasive MenB strain coverage of 4C-MenB.

Funder

RCUK | Medical Research Council

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00204-18

Reference24 articles.

1. Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome Sequencing

2. Transcriptional Regulation of the nadA Gene in Neisseria meningitidis Impacts the Prediction of Coverage of a Multicomponent Meningococcal Serogroup B Vaccine

3. Bexsero