Adapting Microarray Gene Expression Signatures for Early Melioidosis Diagnosis

Author:

Sangwichian Ornuma12,Whistler Toni23ORCID,Nithichanon Arnone1,Kewcharoenwong Chidchamai1,Sein Myint Myint1,Arayanuphum Chawitar4,Chantratita Narisara45,Lertmemongkolchai Ganjana1ORCID

Affiliation:

1. The Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand

2. Thailand Ministry of Public Health–U.S. Centers for Disease Control and Prevention Collaboration (TUC), Nonthaburi, Thailand

3. Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

4. Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

5. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Abstract

Melioidosis is caused by Burkholderia pseudomallei and is predominantly seen in tropical regions. The clinical signs and symptoms of the disease are nonspecific and often result in misdiagnosis, failure of treatment, and poor clinical outcome. Septicemia with septic shock is the most common cause of death, with mortality rates above 40%. Bacterial culture is the gold standard for diagnosis, but it has low sensitivity and takes days to produce definitive results. Early laboratory diagnosis can help guide physicians to provide treatment specific to B. pseudomallei .

Funder

Centre for Research and Development of Medical Diagnostic Laboratories, Khon Kaen University, Thailand

Post doctoral training program, Khon Kaen University, Thailand

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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