Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB-Reference-Cited by-同舟云学术

Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB

Published:2022-10-26 Issue:5 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Li Yingxue¹²^ORCID,Xu Wei²,Ren Yutian²,Cheung Hung-Chi²,Huang Panpan²,Kaur Guneet²,Kuo Chih-Jung³,McDonough Sean P.⁴,Fubini Susan L.⁵,Lipkin Stephen M.⁶,Deng Xin²⁷^ORCID,Chang Yung-Fu⁸^ORCID,Huang Linfeng¹⁹^ORCID

Affiliation:

1. Division of Natural and Applied Sciences, Duke Kunshan University, Kunshan, Jiangsu, China

2. Department of Biomedical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong SAR, China

3. Department of Veterinary Medicine, National Chung Hsing University, Taiwan

4. Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA

5. Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA

6. Weill Cornell Medical College, New York, New York, USA

7. Biotechnology and Health Centre, City University of Hong Kong Shenzhen Research Institute, Shenzhen, China

8. Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA

9. Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China

Abstract

Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea. Toxins, especially TcdB, cause epithelial cell apoptosis, but the underlying cell death mechanism is less clear.

Funder

FHB | Health and Medical Research Fund

National Natural Science Foundation of China

HHS | NIH | National Center for Advancing Translational Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01849-22

Reference65 articles.

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