Hofbauer Cells Spread Listeria monocytogenes among Placental Cells and Undergo Pro-Inflammatory Reprogramming while Retaining Production of Tolerogenic Factors-Reference-Cited by-同舟云学术

Hofbauer Cells Spread Listeria monocytogenes among Placental Cells and Undergo Pro-Inflammatory Reprogramming while Retaining Production of Tolerogenic Factors

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Azari Siavash¹²³^ORCID,Johnson Lauren J.¹²³^ORCID,Webb Amy⁴^ORCID,Kozlowski Sophia M.²,Zhang Xiaoli⁴^ORCID,Rood Kara⁵^ORCID,Amer Amal¹²³^ORCID,Seveau Stephanie¹²³^ORCID

Affiliation:

1. Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

2. Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA

3. Infectious Disease Institute, The Ohio State University, Columbus, Ohio, USA

4. Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA

5. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The Ohio State University, Columbus, Ohio, USA

Abstract

Infection of the placental/fetal unit by the facultative intracellular pathogen Listeria monocytogenes results in severe pregnancy complications. Hofbauer cells (HBCs) are fetal macrophages that play homeostatic anti-inflammatory functions in healthy placentas.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01849-21

Reference122 articles.

1. Pathogens and the placental fortress

2. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus