Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles-Reference-Cited by-同舟云学术

Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles

Published:1997-11 Issue:11 Volume:41 Page:2579-2581
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hantz O¹,Borel C¹,Trabaud C¹,Zoulim F¹,Dessolin J¹,Camplo M¹,Vlieghe P¹,Bouygues M¹,Trepo C¹,Kraus J L¹

Affiliation:

1. Unité de Recherche sur les Hépatites, le SIDA et les Rétrovirus Humains, Institut National de la Santé et de la Recherche Médicale U271, Lyon, France. hantz@lyon151.inserm.fr

Abstract

The antiviral activity of a new class of N,N,N',N",NA'''-pentakis (omega-aminoalkyl) tetraazamacrocycles was evaluated in primary duck hepatocyte cultures infected with the duck hepatitis B virus (DHBV). Three of the four tested compounds were able to selectively inhibit DHBV replication by acting at an early step of the hepadnavirus infection but were associated with significant toxicity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.41.11.2579

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