Moxifloxacin in Chronic Obstructive Pulmonary Disease: Pharmacokinetics and Penetration into Bronchial Secretions in Ward and Intensive Care Unit Patients

Author:

Sionidou Maria1,Manika Katerina1,Pitsiou Georgia2,Kontou Paschalina3,Chatzika Kalliopi1,Zarogoulidis Paul1,Kioumis Ioannis1

Affiliation:

1. Pulmonary Department, Aristotle University of Thessaloniki, G. H. “G. Papanikolaou” (Exohi), Thessaloniki, Greece

2. Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G. H. “G. Papanikolaou” (Exohi), Thessaloniki, Greece

3. 1st Intensive Care Unit, G. H. “G. Papanikolaou” (Exohi), Thessaloniki, Greece

Abstract

This study aimed to evaluate the pharmacokinetic profile of moxifloxacin (MXF) in serum and sputum/bronchial secretions of 22 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) hospitalized in the ward and intensive care unit (ICU). The data showed that ICU patients had lower concentrations in secretions ( P = 0.01).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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