Improvement of the Bioavailability and Anti-hepatic Alveolar Echinococcosis Effect of Albendazole-Isethionate/Hypromellose Acetate Succinate (HPMC-AS) Complex-Reference-Cited by-同舟云学术

Improvement of the Bioavailability and Anti-hepatic Alveolar Echinococcosis Effect of Albendazole-Isethionate/Hypromellose Acetate Succinate (HPMC-AS) Complex

Published:2021-06-17 Issue:7 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hu Chunhui¹²^ORCID,Zhang Fabin¹,Fan Haining³

Affiliation:

1. Medical College, Qinghai University, Qinghai, People’s Republic of China

2. State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Qinghai, People’s Republic of China

3. Department of Hepatopancreatobiliary Surgery, Affiliated Hospital, Qinghai University, Qinghai, People’s Republic of China

Abstract

Maximizing the pharmacodynamics of albendazole (ABZ), which is used to treat echinococcoses, is essential for the long-term treatment of echinococcosis patients. ABZ is a weak base whose solubility depends on the pH value of the solvent.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02233-20

Reference24 articles.

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4. Pharmacology and efficacy of liposome-entrapped albendazole in experimental secondary alveolar echinococcosis and effect of co-administratration with cimetidine

5. Preparation and Characterization of Albendazole β-Cyclodextrin Complexes

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