CAMP Factor of Group B Streptococci: Production, Assay, and Neutralization by Sera from Immunized Rabbits and Experimentally Infected Cows-Reference-Cited by-同舟云学术

CAMP Factor of Group B Streptococci: Production, Assay, and Neutralization by Sera from Immunized Rabbits and Experimentally Infected Cows

Published:1974-02 Issue:2 Volume:9 Page:377-383
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Brown J.¹,Farnsworth R.¹,Wannamaker L. W.¹,Johnson D. W.¹

Affiliation:

1. Departments of Pediatrics and Microbiology, Medical School and the Department of Veterinary Medicine, College of Veterinary Medicine, University of Minnesota, Minneapolis, Minnesota 55455.

Abstract

Quantitative assay methods for CAMP factor activity of group B streptococci and for neutralization of this activity by animal sera are described. The course of the CAMP reaction is influenced by preincubation of red cells with staphylococcal beta-hemolysin and the rate of the reaction by the concentration of CAMP factor. The production of CAMP factor is enhanced by substitution of maltose for glucose in culture broth. Rising inhibitory titers to CAMP activity in sera of rabbits injected with sterile culture supernates of group B streptococci suggest that CAMP factor is an antigen in the rabbit. Cows with experimentally induced group B streptococcal mastitis also demonstrated significant rises in neutralizing titers for CAMP activity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.9.2.377-383.1974

Reference18 articles.

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