Affiliation:
1. Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
Abstract
Watanabe, Tsutomu
(Keio University School of Medicine, Tokyo, Japan),
Chizuko Ogata, and Sachiko Sato
. Episome-mediated transfer of drug resistance in Enterobacteriaceae. VIII. Six-drug-resistance R factor. J. Bacteriol.
88:
922–928. 1964.—The multiple-drug-resistant
Escherichia coli
strain isolated by Lebek in 1963 was found to transfer resistance to sulfonamide, streptomycin, chloramphenicol, tetracycline, kanamycin, and neomycin together by conjugation, as well as by transduction with phage P1kc, suggesting that these drug-resistance markers are carried by a single R factor (R
6
). The results of transductional and spontaneous segregations of the drug-resistance markers of R
6
have shown that R
6
has independent genetic determinants for sulfonamide, streptomycin, chloramphenicol, tetracycline, and kanamycin-neomycin resistance. Resistance to kanamycin and neomycin is probably controlled by a single gene, because no segregation was observed between these two. The resistance transfer factor of R
6
was found to be of the
fi
+
type.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference18 articles.
1. Mutants of Escherichia coli requiring methionine or vitamin B12;DAVIS B. D.;J. Bacteriol.,1950
2. Studies on the mechanism of transfer of drug resistance in bacteria. 34. Transfer of kanamycin resistance;KIMURA S., T.;Med. Biol. (Tokyo),1963
3. Susceptibility and cross resistance of bacteria to streptomycin, neomycin, paromomycin, and kanamycin;KUNIN C. M.;Ann. N. Y. Acad. Sci.,1958
4. Ueber die Entstehung mehrfachresistenter Salmonellen. Ein experimenteller Beitrag;LEBEK G.;Zentr. Bakteriol. Parasitenk. Abt. I Orig.,1963
5. Transduction of linked genetic characters of the host by bacteriophage P1;LENNOX E. S.;Virology,1955
Cited by
53 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献