Antigenic Structure of Human Respiratory Syncytial Virus Fusion Glycoprotein-Reference-Cited by-同舟云学术

Antigenic Structure of Human Respiratory Syncytial Virus Fusion Glycoprotein

Published:1998-08 Issue:8 Volume:72 Page:6922-6928
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

López Juan A.¹,Bustos Regla¹,Örvell Claes²,Berois Mabel³,Arbiza Juan³,García-Barreno Blanca¹,Melero José A.¹

Affiliation:

1. Centro Nacional de Biologı́a Fundamental, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain1;

2. Laboratory of Clinical Virology, Huddinge Hospital, S-141 86 Huddinge, Sweden2; and

3. Sección de Virologı́a, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay3

Abstract

ABSTRACT New series of escape mutants of human respiratory syncytial virus were prepared with monoclonal antibodies specific for the fusion (F) protein. Sequence changes selected in the escape mutants identified two new antigenic sites (V and VI) recognized by neutralizing antibodies and a group-specific site (I) in the F1 chain of the F molecule. The new epitopes, and previously identified antigenic sites, were incorporated into a refined prediction of secondary-structure motifs to generate a detailed antigenic map of the F glycoprotein.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.8.6922-6928.1998

Reference45 articles.

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