Affiliation:
1. Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
Abstract
ABSTRACT
The 8-aminoquinoline tafenoquine showed significant
in vitro
activity against
Leishmania
species, including
L. donovani
amastigotes in macrophages, with 50% inhibitory concentrations (IC
50
s) between 0.1 and 4.0 μM for both pentavalent antimony (SbV)-sensitive and SbV-resistant strains and by oral administration in BALB/c mice, with 50% effective dose (ED
50
) values of 1.2 to 3.5 mg/kg for 5 days. Tafenoquine was less active against intracellular
Trypanosoma cruzi
amastigotes, with an IC
50
of 21.9 μM.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference24 articles.
1. Alvar, J., S. Croft, and P. Olliaro. 2006. Chemotherapy in the treatment and control of leishmaniasis. Adv. Parasitol.61:223-274.
2. Barrett, M. P., D. W. Boykin, R. Brun, and R. R. Tidwell. 2007. Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. Br. J. Pharmacol.152:1155-1171.
3. The activity against Trypanosoma cruzi and cutaneous leishmaniasis, and toxicity, of moxipraquine (349C59)
4. Bradley, D. J., and J. Kirkley. 1977. Regulation of Leishmania populations within the host. I. the variable course of Leishmania donovani infections in mice. Clin. Exp. Immunol.30:119-129.
5. Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase
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