Human herpesvirus 6 infection and Kawasaki disease

Author:

Okano M1,Luka J1,Thiele G M1,Sakiyama Y1,Matsumoto S1,Purtilo D T1

Affiliation:

1. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105-1065.

Abstract

Eighteen of a total of 22 serum specimens (81.8%) from patients with Kawasaki disease were positive for immunoglobulin G or M antibodies to human herpesvirus 6, whereas 10 of 16 age- and sex-matched healthy controls (62.5%) were seropositive. Additionally, increased geometric mean antibody titers of immunoglobulin G were shown in these patients. These results suggest that the status of human herpesvirus 6 infection may be a reflection of the immunologic alterations that are associated with Kawasaki disease.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference7 articles.

1. HBLV (or HHV-6) in human cell lines;Ablashi D. V.;Nature (London),1987

2. Immunoregulatory T cell abnormalities in mucocutaneous Iymph node syndrome;Leung D. Y. M.;J. Immunol.,1983

3. Niederman J. C. C. R. Liu M. H. Kaplan and N. A. Brown. 1988. Clinical and serological features of human herpesvirus-6 infection in three adults. Lancet ii:817-819.

4. Epstein-Barr virus and human diseases: recent advances in diagnosis;Okano M.;Clin. Microbiol. Rev.,1988

5. Kawasaki syndrome;Rowley A. H.;Rev. Infect. Dis.,1988

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