Sphingolipid-Containing Outer Membrane Vesicles Serve as a Delivery Vehicle To Limit Macrophage Immune Response to Porphyromonas gingivalis-Reference-Cited by-同舟云学术

Sphingolipid-Containing Outer Membrane Vesicles Serve as a Delivery Vehicle To Limit Macrophage Immune Response to Porphyromonas gingivalis

Published:2021-03-17 Issue:4 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Rocha Fernanda G.¹,Ottenberg Gregory¹,Eure Zavier G.¹,Davey Mary E.¹^ORCID,Gibson Frank C.¹^ORCID

Affiliation:

1. Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA

Abstract

Sphingolipids (SLs) are essential structural components of mammalian cell membranes. Our group recently determined that the oral anaerobe Porphyromonas gingivalis delivers its SLs to host cells and that the ability of P. gingivalis to synthesize SLs limits the elicited host inflammatory response during cellular infection.

Funder

University of Florida

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00614-20

Reference54 articles.

1. Outer Membrane Vesicles (OMVs) of Gram-negative Bacteria: A Perspective Update

2. Outer Membrane Vesicle-Host Cell Interactions