Early Dissemination of NDM-1- and OXA-181-Producing Enterobacteriaceae in Indian Hospitals: Report from the SENTRY Antimicrobial Surveillance Program, 2006-2007

Author:

Castanheira Mariana1,Deshpande Lalitagauri M.1,Mathai Dilip2,Bell Jan M.3,Jones Ronald N.14,Mendes Rodrigo E.1

Affiliation:

1. JMI Laboratories, North Liberty, Iowa 52317

2. Christian Medical College, Vellore, India

3. SA Pathology, Women's and Children's Hospital, Adelaide, Australia

4. Tufts University School of Medicine, Boston, Massachusetts

Abstract

ABSTRACT Among 39 carbapenem-resistant Enterobacteriaceae (2.7% overall; Escherichia coli , Enterobacter cloacae , and Klebsiella pneumoniae strains) isolated in 2006 and 2007 in India, 15 strains carried bla NDM-1 and 10 harbored a gene encoding a variant of the carbapenemase OXA-48, named bla OXA-181 . One E. cloacae strain harbored bla VIM-6 , and one K. pneumoniae strain carrying bla OXA-181 also possessed bla VIM-5 . Multiple pulsed-field gel electrophoresis patterns and clonal dissemination within and among sites were observed. Isolates producing NDM-1 were disseminated in Indian health care facilities as early as 2006.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference16 articles.

1. Carbapenem Resistance among Pseudomonas aeruginosa Strains from India: Evidence for Nationwide Endemicity of Multiple Metallo-β-Lactamase Clones (VIM-2, -5, -6, and -11 and the Newly Characterized VIM-18)

2. Castanheira, M., J. M. Bell, J. D. Turnidge, R. E. Mendes, and R. N. Jones. 2010. Dissemination and genetic context analysis of blaVIM-6 among Pseudomonas aeruginosa isolates in Asian-Pacific Nations. Clin. Microbiol. Infect. 16:186-189.

3. Centers for Disease Control and Prevention. 2010. Detection of Enterobacteriaceae isolates carrying metallo-beta-lactamase—United States, 2010. MMWR Morb. Mortal. Wkly. Rep. 59:750.

4. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 2009

5. Performance standards for antimicrobial susceptibility testing: 20th informational supplement (June 2010 update) M100-S20-U. 2010

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