In Vitro Antimalarial Activity of Inhibitors of the Human GTPase Rac1-Reference-Cited by-同舟云学术

In Vitro Antimalarial Activity of Inhibitors of the Human GTPase Rac1

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Parapini Silvia¹^ORCID,Paone Silvio²³,Erba Emanuela⁴,Cavicchini Loredana⁵,Pourshaban Manoochehr³,Celani Francesco³,Contini Alessandro⁴,D’Alessandro Sarah⁶^ORCID,Olivieri Anna³^ORCID

Affiliation:

1. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy

2. Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza Università di Roma, Rome, Italy

3. Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy

4. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Milan, Italy

5. Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Milan, Italy

6. Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy

Abstract

Malaria accounts for millions of cases and thousands of deaths every year. In the absence of an effective vaccine, drugs are still the most important tool in the fight against the disease. Plasmodium parasites developed resistance to all classes of known antimalarial drugs.

Funder

Fondazione Cariplo

Ministero della Salute

Regione Lazio

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01498-21

Reference62 articles.

1. WHO. 2020. World malaria report 2020. WHO, Geneva, Switzerland.