Polymyxin Susceptibility Testing and Interpretive Breakpoints: Recommendations from the United States Committee on Antimicrobial Susceptibility Testing (USCAST)-Reference-Cited by-同舟云学术

Polymyxin Susceptibility Testing and Interpretive Breakpoints: Recommendations from the United States Committee on Antimicrobial Susceptibility Testing (USCAST)

Published:2020-01-27 Issue:2 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pogue Jason M.¹,Jones Ronald N.²,Bradley John S.³⁴,Andes David R.⁵,Bhavnani Sujata M.⁶,Drusano George L.⁷,Dudley Michael N.⁸,Flamm Robert K.⁹,Rodvold Keith A.¹⁰,Ambrose Paul G.⁶

Affiliation:

1. University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA

2. USCAST, Silverton, Oregon, USA

3. University of San Diego, San Diego, California, USA

4. Rady Children’s Hospital, San Diego, California, USA

5. University of Wisconsin, Madison, Wisconsin, USA

6. ICPD, Schenectady, New York, USA

7. Institute for Therapeutic Innovation, College of Medicine, University of Florida, Lake Nona, Florida, USA

8. Qpex Biopharma, San Diego, California, USA

9. JMI Laboratories, North Liberty, Iowa, USA

10. University of Illinois at Chicago, College of Pharmacy, Chicago, Illinois, USA

Abstract

The polymyxins are important agents for carbapenem-resistant Gram-negative bacilli. The United States Committee on Antimicrobial Susceptibility Testing breakpoint recommendations for colistin and polymyxin B are that isolates of Pseudomonas aeruginosa , Acinetobacter baumannii , and Enterobacteriaceae are considered susceptible at MIC values of ≤2 mg/liter. These recommendations are contingent upon dosing and testing strategies that are described in this commentary.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01495-19

Reference74 articles.

1. CLSI. 2019. M100Ed29. Performance standards for antimicrobial susceptibility testing: 29th informational supplement. Clinical and Laboratory Standards Institute, Wayne, PA.

2. EUCAST. 2019. Breakpoint tables for interpretation of MICs and zone diameters. Version 9.0 January 2019. http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_9.0_Breakpoint_Tables.pdf. Accessed January 2019.

3. NCCLS. 1981. M2-A02-S1. Performance standards for antimicrobial disc susceptibility tests; approved standard. First supplement. National Committee for Clinical Laboratory Standards, Villanova, PA.

4. NCCLS. 1982. M2-A02-S2. Performance standards for antimicrobial disc susceptibility tests; approved standard. Second supplement. National Committee for Clinical and Laboratory Standards, Villanova, PA.

5. NCCLS. 1980. PSM-7. Standard methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Proposed standard. National Committee for Clinical Laboratory Standards, Villanova, PA.

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