Positron Emission Tomography-Based Pharmacokinetic Analysis To Assess Renal Transporter-Mediated Drug-Drug Interactions of Antimicrobial Drugs-Reference-Cited by-同舟云学术

Positron Emission Tomography-Based Pharmacokinetic Analysis To Assess Renal Transporter-Mediated Drug-Drug Interactions of Antimicrobial Drugs

Published:2023-02-14 Issue: Volume: Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hernández-Lozano Irene¹,Mairinger Severin¹²,Filip Thomas³⁴,Löbsch Mathilde³,Stanek Johann²,Kuntner Claudia²,Bauer Martin¹,Zeitlinger Markus¹^ORCID,Hacker Marcus²,Helbich Thomas H.²,Wanek Thomas²,Langer Oliver¹²^ORCID

Affiliation:

1. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

2. Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria

3. Core Facility Laboratory Animal Breeding and Husbandry, Medical University of Vienna, Vienna, Austria

4. Center for Biomedical Research, Medical University of Vienna, Vienna, Austria

Abstract

Transporter-mediated drug-drug interactions (DDIs) are of concern in antimicrobial drug development, as they can have serious safety consequences. We used positron emission tomography (PET) imaging-based pharmacokinetic (PK) analysis to assess the effect of different drugs, which may cause transporter-mediated DDIs, on the tissue distribution and excretion of [ 18 F]ciprofloxacin as a radiolabeled model antimicrobial drug.

Funder

Austrian Science Fund

Society for Research Promotion Lower Austria

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01493-22

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