Association of Selective HLA Class II Susceptibility-Conferring and Protective Haplotypes with Type 2 Diabetes in Patients from Bahrain and Lebanon-Reference-Cited by-同舟云学术

Association of Selective HLA Class II Susceptibility-Conferring and Protective Haplotypes with Type 2 Diabetes in Patients from Bahrain and Lebanon

Published:2006-11 Issue:11 Volume:13 Page:1296-1298
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Almawi Wassim Y.¹²³⁴,Wakim-Ghorayeb Saria F.¹²³⁴,Arekat Mona R.¹²³⁴,Najm Pierre¹²³⁴,Keleshian Sose H.¹²³⁴,Al-Sayed Nasreen¹²³⁴,Blanchon Bruno¹²³⁴,Samaha Hanady R.¹²³⁴,Irani-Hakime Noha¹²³⁴

Affiliation:

1. College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain

2. St. Georges University Hospital, Beirut, Lebanon

3. Joslin Diabetes Center-Bahrain, Manama, Bahrain

4. Haigazian University, Beirut, Lebanon

Abstract

ABSTRACT The association of HLA class II with type 2 diabetes (T2DM) was investigated in Bahraini and Lebanese subjects. DRB1*070101 (Lebanese and Bahraini) and DQB1*0201 (Lebanese) were susceptibility-conferring alleles, and unique susceptibility-conferring/protective haplotypes were found in both patient groups. Regression analysis confirmed that DRB1*070101-DQB1*0201 (Bahraini) and DRB1*110101-DQB1*0201 (Lebanese) were susceptibility-conferring haplotypes.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00206-06

Reference20 articles.

1. Al-Jenaidi, F. A., S. F. Wakim-Ghorayeb, A. Al-Abbasi, M. R. Arekat, N. Irani-Hakime, P. Najm, K. Al-Ola, A. A. Motala, and W. Y. Almawi. 2005. Contribution of selective HLA-DRB1/DQB1 alleles and haplotypes to the genetic susceptibility of type 1 diabetes among Lebanese and Bahraini Arabs. J. Clin. Endocrinol. Metab.90:5104-5109.

2. Al-Mahroos, F., and P. M. McKeigue. 1998. High prevalence of diabetes in Bahrainis. Associations with ethnicity and raised plasma cholesterol. Diabetes Care21:936-942.

3. Almawi, W. Y., M. Busson, H. Tamim, E. M. Al-Harbi, R. R. Finan, S. F. Wakim-Ghorayeb, and A. A. Motala. 2004. HLA class II profile and distribution of HLA-DRB1 and HLA-DQB1 alleles and haplotypes among Lebanese and Bahraini Arabs. Clin. Diagn. Lab. Immunol.11:770-774.

4. Bach, J. M., H. Otto, G. T. Nepom, G. Jung, H. Cohen, J. Timsit, C. Boitard, and P. M. van Endert. 1997. High affinity presentation of an autoantigenic peptide in type I diabetes by an HLA class II protein encoded in a haplotype protecting from disease. J. Autoimmun.10:375-386.

5. Barroso, I. 2005. Genetics of type 2 diabetes. Diabet. Med.22:517-535.

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