In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides-Reference-Cited by-同舟云学术

In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides

Published:2001-11 Issue:11 Volume:45 Page:3209-3212
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bergsson Gudmundur¹,Arnfinnsson Jóhann²,Steingrı́msson Ólafur³,Thormar Halldor¹

Affiliation:

1. Institute of Biology, University of Iceland,1

2. Department of Anatomy, University of Iceland Medical School,2 and

3. Department of Microbiology, National University Hospital,3 Reykjavik, Iceland

Abstract

ABSTRACT The susceptibility of Candida albicans to several fatty acids and their 1-monoglycerides was tested with a short inactivation time, and ultrathin sections were studied by transmission electron microscopy (TEM) after treatment with capric acid. The results show that capric acid, a 10-carbon saturated fatty acid, causes the fastest and most effective killing of all three strains of C. albicans tested, leaving the cytoplasm disorganized and shrunken because of a disrupted or disintegrated plasma membrane. Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.11.3209-3212.2001

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