Two New Point Mutations at A2062 Associated with Resistance to 16-Membered Macrolide Antibiotics in Mutant Strains of Mycoplasma hominis-Reference-Cited by-同舟云学术

Two New Point Mutations at A2062 Associated with Resistance to 16-Membered Macrolide Antibiotics in Mutant Strains of Mycoplasma hominis

Published:2001-10 Issue:10 Volume:45 Page:2958-2960
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Furneri Pio Maria¹,Rappazzo Giancarlo²,Musumarra Maria Pia¹,Di Pietro Patrizia¹,Catania Lucrezia S.¹,Roccasalva Lucia Silvana¹

Affiliation:

1. Dipartimento di Scienze Microbiologiche e Scienze Ginecologiche1 and

2. Dipartimento di Biologia Animale,2 Università degli Studi, Catania, Italia

Abstract

ABSTRACT We describe two mutants of Mycoplasma hominis PG-21 which show resistance to 16-membered macrolides but susceptibility to lincosamides, obtained by in vitro exposure to increasing doses of josamycin. The 23S rRNA gene showed that each had a mutation (A2062G and A2062T) corresponding to nucleotide 2062 in Escherichia coli , which was associated with the acquired phenotype.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.10.2958-2960.2001

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