SHV-14, a Novel β-Lactamase Variant in Klebsiella pneumoniae Isolates from Nijmegen, The Netherlands-Reference-Cited by-同舟云学术

SHV-14, a Novel β-Lactamase Variant in Klebsiella pneumoniae Isolates from Nijmegen, The Netherlands

Published:2001-01 Issue:1 Volume:45 Page:309-311
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yuan Meifang¹,Hall Lucinda M. C.¹,Hoogkamp-Korstanje Jaa²,Livermore David M.³

Affiliation:

1. Department of Medical Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London E1 2AD,1 and

2. Department of Medical Microbiology, University Hospital St. Radboud, Nijmegen, The Netherlands2

3. Antibiotic Resistance Monitoring & Reference Laboratory, Central Public Health Laboratory, London NW9 5HT,3 United Kingdom, and

Abstract

ABSTRACT Four ceftazidime-resistant isolates of a Klebsiella pneumoniae strain were collected from intensive care unit patients in Nijmegen, The Netherlands. These isolates had TEM-29 and SHV-14 β-lactamases. SHV-14 is a novel variant, with two substitutions compared with the sequence of SHV-1: Ile8Phe and Arg43Ser. Its gene also had a silent C→T mutation at nucleotide 481. The SHV-14 enzyme had slightly higher V max rates than SHV-1 for oxyimino-aminothiazolyl cephalosporins, but this activity was insufficient for the enzyme to count as an extended-spectrum β-lactamase.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.1.309-311.2001

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