Effects of New Quinolones on Transepithelial Electrical Potential Difference of Tracheal Mucosa In Vivo-Reference-Cited by-同舟云学术

Effects of New Quinolones on Transepithelial Electrical Potential Difference of Tracheal Mucosa In Vivo

Published:2001-10 Issue:10 Volume:45 Page:2928-2930
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kanoh Soichiro¹,Tamaoki Jun¹,Kondo Mitsuko¹,Nagano Yuko¹,Nagai Atsushi¹

Affiliation:

1. First Department of Medicine, Tokyo Women's Medical University School of Medicine, Tokyo 162-8666, Japan

Abstract

ABSTRACT Superfusion of canine tracheal mucosa with 100 μg each of grepafloxacin and ciprofloxacin per ml reduced the electrical transepithelial potential difference in vivo by more than 50%. This effect was dose dependent, specific for new quinolones, and inhibited by Cl channel blockers, indicating that new quinolones attenuate Cl secretion across the airway epithelium.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.10.2928-2930.2001

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