Postantibiotic Effects of Antituberculosis Agents Alone and in Combination-Reference-Cited by-同舟云学术

Postantibiotic Effects of Antituberculosis Agents Alone and in Combination

Published:2001-12 Issue:12 Volume:45 Page:3631-3634
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chan Chiu-Yeung¹,Au-Yeang Carrie¹,Yew Wing-Wai²,Hui Mamie¹,Cheng Augustine F. B.¹

Affiliation:

1. Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories,1 and

2. Tuberculosis & Chest Unit, Grantham Hospital, Aberdeen,2 Hong Kong

Abstract

ABSTRACT The postantibiotic effects (PAEs) of seven antimycobacterial agents, tested at their respective peak concentrations in serum alone and in different combinations, against Mycobacterium tuberculosis ATCC 27294 were studied with a radiometric culture system in parallel with the viable count method. Rifampin gave the longest PAE (67.8 h) among the drugs used alone, and combinations of first-line drugs generally gave PAEs longer than 120 h. The data obtained might help provide a better understanding of the scientific basis of intermittently administered antituberculosis chemotherapy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.12.3631-3634.2001

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