Elements of the polyomavirus replication origin required for homologous recombination mediated by large T antigen-Reference-Cited by-同舟云学术

Elements of the polyomavirus replication origin required for homologous recombination mediated by large T antigen

Published:1995-11 Issue:11 Volume:69 Page:7304-7308
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Laurent S¹,Bastin M¹

Affiliation:

1. Department of Biochemistry, University of Sherbrooke, Quebec, Canada.

Abstract

We introduced various elements of the polyomavirus origin of DNA replication into the genome of rat cells, and we analyzed their capacity to elicit rearrangements within the integrated sequences when exposed to large T antigen. The cis-acting sequences required for homologous recombination were those that make up a functional replication origin.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.69.11.7304-7308.1995

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