Affiliation:
1. Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706
Abstract
ABSTRACT
The
YPS3
locus of the dimorphic fungus
Histoplasma capsulatum
encodes a secreted and surface-localized protein specific to the pathogenic yeast phase. In this study we examined this locus in 32
H. capsulatum
strains and variants. Although protein production is limited to a select group of strains, the North American restriction fragment length polymorphism class 2/NAm 2 isolates, the locus was present in all the strains we examined. The
YPS3
gene is well conserved in its 5′ and 3′ regions but displays an intragenic hypervariable region of tandem repeats that fluctuates in size between strains. This feature is similar to that seen with genes encoding several cell surface proteins in other fungi.
Publisher
American Society for Microbiology
Subject
Molecular Biology,General Medicine,Microbiology
Cited by
29 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献