Zebrafish <i>maoc1</i> Attenuates Spring Viremia of Carp Virus Propagation by Promoting Autophagy-Lysosome-Dependent Degradation of Viral Phosphoprotein-Reference-Cited by-同舟云学术

Zebrafish maoc1 Attenuates Spring Viremia of Carp Virus Propagation by Promoting Autophagy-Lysosome-Dependent Degradation of Viral Phosphoprotein

Published:2023-02-28 Issue:2 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Song Yanan¹²,Fan Sijia²,Zhang Dawei²,Li Jun²,Li Zhi²,Li Ziyi²,Xiao Wuhan²³⁴⁵,Wang Jing²³⁴^ORCID

Affiliation:

1. College of Fisheries and Life Science, Dalian Ocean University, Dalian, People’s Republic of China

2. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, People’s Republic of China

3. The Innovation Academy of Seed Design, Chinese Academy of Sciences, Wuhan, People’s Republic of China

4. University of Chinese Academy of Sciences, Beijing, People’s Republic of China

5. Hubei Hongshan Laboratory, Wuhan, People’s Republic of China

Abstract

SVCV P protein plays an essential role in the virus replication and viral immune evasion process. Here, we identify maoc1 as a novel SVCV-inducible gene and demonstrate its antiviral capacity through attenuating SVCV replication, by directly binding to P protein and mediating its degradation via the autophagy-lysosomal pathway.

Funder

National Natural Science Foundation of China

Strategic Priority Research Program of China Academy of Sciences

MOST | National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01338-22

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1. Emerging viruses in aquaculture