Affiliation:
1. National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Bangkok 10400, Thailand
Abstract
ABSTRACT
Bioassay-guided fractionation of the extract from the fermentation broth of
Streptomyces
spectabilis
BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A
1
, and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against
Plasmodium
falciparum
K1, with a 50% inhibitory concentration of 0.0050 ± 0.0010 μg/ml, while its cytotoxicity was much weaker.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
85 articles.
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