Lack of Catheter Infection by the efg1 / efg1 cph1 / cph1 Double-Null Mutant, a Candida albicans Strain That Is Defective in Filamentous Growth

Abstract

ABSTRACT The molecular controls regulating the successful colonization of Candida albicans on foreign materials are not known. Here we show that a mutant C. albicans strain defective in filamentous growth and lacking the transcription factors Efg1p and Cph1p has a profoundly deficient potential for colonizing on polyurethane catheters.