Production of Norspermidine Contributes to Aminoglycoside Resistance in pmrAB Mutants of Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Production of Norspermidine Contributes to Aminoglycoside Resistance in pmrAB Mutants of Pseudomonas aeruginosa

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bolard Arnaud¹²,Schniederjans Monika³,Haüssler Susanne³,Triponney Pauline¹,Valot Benoît²,Plésiat Patrick¹²^ORCID,Jeannot Katy¹²

Affiliation:

1. Centre National de Référence de la Résistance aux Antibiotiques, Centre Hospitalier Universitaire de Besançon, Besançon, France

2. UMR6249 Chrono-environnement, Faculté de Médecine-Pharmacie, Université de Bourgogne-Franche Comté, Besançon, France

3. Molecular Bacteriology, Twincore, Centre for Experimental and Clinical Infection Research, a joint venture of the Helmholtz Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany

Abstract

Emergence of resistance to polymyxins in Pseudomonas aeruginosa is mainly due to mutations in two-component systems that promote the addition of 4-amino-4-deoxy- l -arabinose to the lipopolysaccharide (LPS) through upregulation of operon arnBCADTEF-ugd ( arn ) expression. Here, we demonstrate that mutations occurring in different domains of histidine kinase PmrB or in response regulator PmrA result in coresistance to aminoglycosides and colistin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01044-19

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