Periodontitis Vaccine Decreases Local Prostaglandin E 2 Levels in a Primate Model

Abstract

ABSTRACT Interleukin-1β, tumor necrosis factor alpha, prostaglandin E 2 (PGE 2 ), and Porphyromonas gingivalis- specific immunoglobulin G levels in gingival crevicular fluid were measured in primates immunized with a P. gingivalis vaccine followed by ligature-induced periodontitis. Only PGE 2 levels were dramatically suppressed ( P < 0.0001) in immunized animals versus controls. A significant correlation ( P < 0.027) was also found between PGE 2 levels and decreased bone loss scores. This study presents the first evidence of a potential mechanism involved in periodontitis vaccine-induced suppression of bone loss in a nonhuman primate model and offers insight into the role of PGE 2 in periodontal destruction.