Production of a mutagen from ponceau 3R by a human intestinal anaerobe

Author:

Hartman C P,Andrews A W,Chung K T

Abstract

Ponceau 3R was reduced in vitro by Fusobacterium sp. 2, a human intestinal anaerobe, to a product which is mutagenic when metabolically activated by liver S9 preparations in the Salmonella/mammalian-microsome mutagenicity test. This mutagenic metabolite has been identified as 2,4,5-trimethylaniline.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference9 articles.

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3. Tryptophanase of fecal flora as a possible factor in the etiology of colon cancer;Chung K.;J. Natl. Cancer Inst.,1975

4. Holdeman L. V. and W. E. C. Moore. 1972. Anaerobe laboratory manual. Anaerobe laboratory Virginia Polytechnic Institute and State University Blacksburg.

5. IARC monograph on the evaluation of carcinogenic risk of chemicals to man, some aromatic azo compounds;International Agency for Research on Cancer.;WHO Monogr. Ser.,1974

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