Biosynthesis of Monensin-Reference-Cited by-同舟云学术

Biosynthesis of Monensin

Published:1973-10 Issue:4 Volume:4 Page:410-414
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Day L. E.¹,Chamberlin J. W.¹,Gordee E. Z.¹,Chen S.¹,Gorman M.¹,Hamill R. L.¹,Ness T.¹,Weeks R. E.¹,Stroshane R.¹

Affiliation:

1. Eli Lilly and Company, Indianapolis, Indiana 46206

Abstract

The biosynthesis of monensin by Streptomyces cinnamonensis was studied by using 14 C-labeled glucose, acetate, propionate, butyrate, and methionine. The results indicated that the antibiotic is synthesized from five acetate, seven propionate, and one butyrate molecules. The o -methyl group of monensin is derived from methionine, whereas the terminal hydroxymethyl group is incorporated from acetate.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.4.4.410

Reference10 articles.

1. Monensin, a new biologically active compound;Agtarap A.;IV. Chemistry. Antimicrob. Ag. Chemother.,1968

2. The structure of monensic acid, a new biologically active compound;Agtarap A.;J. Amer. Chem. Soc.,1967

3. Monensin, a new biologically active compound. V. Compounds related to monensin;Gorman M.;Antimicrob. Ag. Chemother.,1968

4. Monensin, a new biologically active compound. I. Discovery and isolation;Haney M. E.;Antimicrob. Ag. Chemother.,1968

5. The biosynthesis of the macrolide antibiotic Iucensomycin;Manwaring D. G.;J. Antibiot.,1969

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