Metagenomic Sequencing as a Pathogen-Agnostic Clinical Diagnostic Tool for Infectious Diseases: a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies-Reference-Cited by-同舟云学术

Metagenomic Sequencing as a Pathogen-Agnostic Clinical Diagnostic Tool for Infectious Diseases: a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies

Published:2021-08-18 Issue:9 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Govender Kumeren N.¹^ORCID,Street Teresa L.¹,Sanderson Nicholas D.¹,Eyre David W.¹²

Affiliation:

1. Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom

2. Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

Abstract

Metagenomic sequencing is frequently claimed to have the potential to revolutionize microbiology through rapid species identification and antimicrobial resistance (AMR) prediction. We assess the progress toward these developments.

Funder

NIHR | NIHR Oxford Biomedical Research Centre

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02916-20

Reference40 articles.

1. Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products

2. DNA extraction from primary liquid blood cultures for bloodstream infection diagnosis using whole genome sequencing

3. Direct Detection and Identification of Prosthetic Joint Infection Pathogens in Synovial Fluid by Metagenomic Shotgun Sequencing