A Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 Levels-Reference-Cited by-同舟云学术

A Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 Levels

Published:2020-04-13 Issue:9 Volume:40 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Chaudhary Ritu¹,Muys Bruna R.¹,Grammatikakis Ioannis¹,De Supriyo²,Abdelmohsen Kotb²,Li Xiao Ling¹,Zhu Yuelin³,Daulatabad Swapna Vidhur⁴,Tsitsipatis Dimitrios²,Meltzer Paul S.³,Gorospe Myriam²,Janga Sarath Chandra⁴,Lal Ashish¹

Affiliation:

1. Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

2. Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA

3. Molecular Genetics Section, Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

4. Department of BioHealth Informatics, School of Informatics and Computing, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA

Abstract

Circular RNAs (circRNAs) are a class of noncoding RNAs produced by a noncanonical form of alternative splicing called back-splicing. To investigate a potential role of circRNAs in the p53 pathway, we analyzed RNA sequencing (RNA-seq) data from colorectal cancer cell lines (HCT116, RKO, and SW48) that were untreated or treated with a DNA-damaging agent. Surprisingly, unlike the strong p53-dependent induction of hundreds of p53-induced mRNAs upon DNA damage, only a few circRNAs were upregulated from p53-induced genes.

Funder

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00473-19

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