Prospective Study of Fecal Colonization by Extended-Spectrum-β-Lactamase-Producing Escherichia coli in Neutropenic Patients with Cancer

Author:

Calatayud L.12,Arnan M.3,Liñares J.12,Dominguez M. A.1,Gudiol C.4,Carratalà J.4,Batlle M.5,Ribera J. M.5,Gudiol F.4

Affiliation:

1. Microbiology Department, Hospital Universitari de Bellvitge, University of Barcelona, IDIBELL, Barcelona

2. Ciber de Enfermedades Respiratorias, ISCIII, Madrid

3. Hematology Department, Hospital Duran y Reynals, Barcelona

4. Infectious Diseases Department, Hospital Universitari de Bellvitge, University of Barcelona, IDIBELL, Barcelona

5. Hematology Department, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

Abstract

ABSTRACT Fecal colonization by extended-spectrum-β-lactamase-producing Escherichia coli in 912 stool samples collected from 154 neutropenic patients with cancer, hospitalized at two teaching institutions, was prospectively studied. Forty-nine (31.8%) patients were colonized, 22 of them at hospital admission. Most strains were clonally unrelated and carried a CTX-M-9 group enzyme.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference23 articles.

1. Growing Group of Extended-Spectrum β-Lactamases: the CTX-M Enzymes

2. Emergence of fluoroquinolone-resistant Escherichia coli in fecal flora of cancer patients receiving norfloxacin prophylaxis

3. CLSI/NCCLS document M100-369 S15. 2007

4. Molecular Epidemiology of Extended-Spectrum β-Lactamases among Escherichia coli Isolates Collected in a Swedish Hospital and Its Associated Health Care Facilities from 2001 to 2006

5. Hughes, W. T., D. Armstrong, G. P. Bodey, E. J. Bow, A. E. Brown, T. Calandra, R. Feld, P. A. Pizzo, K. V. Rolston, J. L. Shenep, and L. S. Young. 2002. Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin. Infect. Dis.15:730-751.

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