The Antifungal Polyketide Ambruticin Targets the HOG Pathway-Reference-Cited by-同舟云学术

The Antifungal Polyketide Ambruticin Targets the HOG Pathway

Published:2007-10 Issue:10 Volume:51 Page:3734-3736
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Vetcher Leandro¹,Menzella Hugo G.¹,Kudo Toshiaki²,Motoyama Takayuki²,Katz Leonard¹

Affiliation:

1. Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, California 94545

2. RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Abstract

ABSTRACT The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of action has not yet been elucidated. Here we present evidence that ambruticin exerts its effect by targeting HOG, the osmotic stress control pathway, through Hik1, a group III histidine kinase.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00369-07

Reference20 articles.

1. Avenot, H., P. Simoneau, B. Iacomi-Vasilescu, and N. Bataille-Simoneau. 2005. Characterization of mutations in the two-component histidine kinase gene AbNIK1 from Alternaria brassicicola that confer high dicarboximide and phenylpyrrole resistance. Curr. Genet.47:234-243.

2. Whole-Genome Analysis of Two-Component Signal Transduction Genes in Fungal Pathogens

3. Efficacy of Ambruticin Analogs in a Murine Model of Invasive Pulmonary Aspergillosis

4. Connor, D. T., R. C. Greenough, and M. von Strandtmann. 1977. W-7783, a unique antifungal antibiotic. J. Org. Chem.42:3664-3669.

5. Cui, W., R. E. Beever, S. L. Parkes, P. L. Weeds, and M. D. Templeton. 2002. An osmosensing histidine kinase mediates dicarboximide fungicide resistance in Botryotinia fuckeliana (Botrytis cinerea). Fungal Genet. Biol.36:187-198.

Cited by 46 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. An Overview of Julia-lythgoe Olefination;Current Organic Synthesis;2024-03

2. Myxobacteria: biology and bioactive secondary metabolites;Research in Microbiology;2023-09

3. Examination of Secondary Metabolite Biosynthesis in Apicomplexa;ChemBioChem;2023-07-27

4. The Corey-Seebach Reagent in the 21st Century: A Review;Molecules;2023-05-26

5. Current Antifungal Drugs;Current Trends in the Identification and Development of Antimicrobial Agents;2023-03-07