Affiliation:
1. Mycobacteriology Unit, Center for Disease Control, Atlanta, Georgia 30333
Abstract
The
Mycobacterium
species
M. tuberculosis, M. avium-intracellulare, M. kansasii, M. marinum, M. scrofulaceum, M. fortuitum, M. terrae
, and
M. gordonae
were analyzed for their susceptibility to rifampin.
M. tuberculosis, M. kansasii
, and
M. marinum
were susceptible to the antibiotic, and resistant populations developed as a result of the interplay of mutation and selection. The mutation rates (susceptibility → resistance) were calculated to be 4.9 × 10
−10
and 1.7 × 10
−9
mutations per bacterium per generation in, respectively,
M. kansasii
and
M. marinum. M. fortuitum
was found to be naturally resistant to the antibiotic, whereas the nature of resistance in the other species was unclear and is discussed.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
28 articles.
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