Author:
Denkers Nathaniel D.,Hayes-Klug Jeanette,Anderson Kelly R.,Seelig Davis M.,Haley Nicholas J.,Dahmes Sallie J.,Osborn David A.,Miller Karl V.,Warren Robert J.,Mathiason Candace K.,Hoover Edward A.
Abstract
ABSTRACTWhile the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of CWD to deer with a prion dose >20-fold lower than that used in previous oral inoculations. Inhalation of prions may facilitate transmission of CWD and, perhaps, other prion infections.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Cited by
58 articles.
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