Affiliation:
1. Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
Abstract
How surfaces influence cell size, cell-cell interactions, and population migration for robust swarmers like
P. mirabilis
is not fully understood. Here, we have elucidated how cells change length along a spectrum of sizes that positively correlates with increases in agar concentration, regardless of population migration. Single-cell phenotypes can be decoupled from collective population migration simply by increasing agar concentration. A cell’s lipopolysaccharides function to broaden the range of agar conditions under which cell elongation and single-cell motility remain coupled with population migration. In eukaryotes, the physical environment, such as a surface matrix, can impact cell development, shape, and migration. These findings support the idea that rigid surfaces similarly act on swarming bacteria to impact cell shape, single-cell motility, and collective population migration.
Funder
Smith Family Graduate Fellowship in Science and Engineering
George W. Merck Fund
David and Lucile Packard Foundation
Harvard University
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
21 articles.
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