The Small-Compound Inhibitor K22 Displays Broad Antiviral Activity against Different Members of the Family Flaviviridae and Offers Potential as a Panviral Inhibitor-Reference-Cited by-同舟云学术

The Small-Compound Inhibitor K22 Displays Broad Antiviral Activity against Different Members of the Family Flaviviridae and Offers Potential as a Panviral Inhibitor

Published:2018-11 Issue:11 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

García-Nicolás Obdulio¹²,V'kovski Philip¹²³,Vielle Nathalie J.¹²³,Ebert Nadine¹²,Züst Roland⁴,Portmann Jasmine¹²,Stalder Hanspeter¹²,Gaschen Véronique⁵,Vieyres Gabrielle⁶,Stoffel Michael⁵,Schweizer Matthias¹²^ORCID,Summerfield Artur¹²,Engler Olivier⁴,Pietschmann Thomas⁶^ORCID,Todt Daniel⁷,Alves Marco P.¹²,Thiel Volker¹²,Pfaender Stephanie¹²

Affiliation:

1. Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland

2. Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

3. Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

4. Spiez Laboratory, Spiez, Switzerland

5. Division of Veterinary Anatomy, Department of Clinical Research, Vetsuisse Faculty, University of Bern, Bern, Switzerland

6. Institute for Experimental Virology, Twincore Centre for Experimental and Clinical Infection Research, Hannover, Germany

7. Department of Molecular and Medical Virology, Ruhr-University Bochum, Bochum, Germany

Abstract

The virus family Flaviviridae encompasses several viruses, including (re)emerging viruses which cause widespread morbidity and mortality throughout the world. Members of this virus family are positive-strand RNA viruses and replicate their genome in close association with reorganized intracellular host cell membrane compartments.

Funder

European Union Horizon 2020 Research and Innovation Programme

Helmholtz Alberta Initiative for infectious Disease Research

Swiss National Science Foundation

Seventh Framework Programme

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01206-18

Reference44 articles.