Induction of Apoptosis by a Nonnucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor-Reference-Cited by-同舟云学术

Induction of Apoptosis by a Nonnucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor

Published:2002-08 Issue:8 Volume:46 Page:2687-2691
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pilon A. A.¹,Lum J. J.¹,Sanchez-Dardon J.¹,Phenix B. N.¹,Douglas R.¹,Badley A. D.¹²

Affiliation:

1. Ottawa Health Research Institute, HIV Research Laboratory, Ottawa, Ontario, Canada K1H 8L6

2. Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905

Abstract

ABSTRACT Inhibition of human immunodeficiency virus type 1 reverse transcriptase (RT) by both nucleoside and nonnucleoside RT inhibitors profoundly inhibits virus replication. Nucleoside RT inhibitors are known to be toxic, but there is little information regarding the toxicities of nonnucleoside RT inhibitors (NNRTI). We demonstrate that efavirenz (an NNRTI) induces caspase- and mitochondrion-dependent apoptosis of Jurkat T cells and human peripheral blood mononuclear cells. The clinical relevance of these observations is not yet clear.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.8.2687-2691.2002

Reference21 articles.

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