Chemiosmotic Mechanism of Antimicrobial Activity of Ag + in Vibrio cholerae-Reference-Cited by-同舟云学术

Chemiosmotic Mechanism of Antimicrobial Activity of Ag + in Vibrio cholerae

Published:2002-08 Issue:8 Volume:46 Page:2668-2670
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dibrov Pavel¹,Dzioba Judith¹,Gosink Khoosheh K.²,Häse Claudia C.²

Affiliation:

1. Department of Microbiology, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada

2. Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105

Abstract

ABSTRACT Although the antimicrobial effects of silver salts were noticed long ago, the molecular mechanism of the bactericidal action of Ag + in low concentrations has not been elucidated. Here, we show that low concentrations of Ag + induce a massive proton leakage through the Vibrio cholerae membrane, which results in complete deenergization and, with a high degree of probability, cell death.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.8.2668-2670.2002

Reference14 articles.

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