Decay of Human Immunodeficiency Virus Type 1 Unintegrated DNA Containing Two Long Terminal Repeats in Infected Individuals after 3 to 8 Years of Sustained Control of Viremia-Reference-Cited by-同舟云学术

Decay of Human Immunodeficiency Virus Type 1 Unintegrated DNA Containing Two Long Terminal Repeats in Infected Individuals after 3 to 8 Years of Sustained Control of Viremia

Published:2005-10 Issue:10 Volume:43 Page:5272-5274
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

McDermott Jennifer L.¹²,Martini Isabella¹²,Ferrari Davide¹²,Bertolotti Francesca¹,Giacomazzi Claudio¹²,Murdaca Giuseppe³,Puppo Francesco³,Indiveri Francesco³,Varnier Oliviero E.¹²

Affiliation:

1. Sections of Microbiology

2. Diagnostic Microbiology of Infectious Diseases, Advanced Biotechnology Center, Genova, Italy

3. Internal Medicine and Clinical Immunology, School of Medicine, University of Genova

Abstract

ABSTRACT Covert human immunodeficiency virus (HIV) replication was ongoing during the first 3 years of aviremia in 22 patients, as determined by detection of DNA containing two long terminal repeats (2LTR DNA). Although total HIV DNA was detected in 60 2LTR DNA-negative samples, the absence of 2LTR DNA in 90% of patients following 7 to 8 years of highly active antiretroviral therapy suggests suppression of cryptic viral replication.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.43.10.5272-5274.2005

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