Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in Mice-Reference-Cited by-同舟云学术

Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in Mice

Published:2021-01-13 Issue:3 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Gutierrez-Alvarez Javier¹,Wang Li¹,Fernandez-Delgado Raul¹,Li Kun²,McCray Paul B.²,Perlman Stanley³⁴^ORCID,Sola Isabel¹,Zuñiga Sonia¹,Enjuanes Luis¹^ORCID

Affiliation:

1. Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain

2. Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

3. Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

4. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus causing human infections with high mortality rate (∼35%). Animal models together with reverse-genetics systems are essential to understand MERS-CoV pathogenesis. We developed a reverse-genetics system for a mouse-adapted MERS-CoV that reproduces the virus behavior observed in humans. This system is highly useful to investigate the role of specific viral genes in pathogenesis. In addition, we described a virus lacking gene 5 expression that is more virulent than the parental one. The data provide novel functions in IFN modulation for gene 5 in the context of viral infection and will help to develop novel antiviral strategies.

Funder

Government of Spain

European Union

HHS | National Institutes of Health

MEC | Consejo Superior de Investigaciones Científicas

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01172-20

Reference70 articles.

1. Novel coronavirus associated with severe respiratory disease: Case definition and public health measures

2. Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

3. Update: severe respiratory illness associated with Middle East respiratory syndrome coronavirus (MERS-CoV)—worldwide, 2012-2013;MMWR;MMWR Morb Mortal Wkly Rep,2013

4. Research needed to prevent MERS coronavirus outbreaks

5. Cross host transmission in the emergence of MERS coronavirus

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