Levels of Influenza A Virus Defective Viral Genomes Determine Pathogenesis in the BALB/c Mouse Model-Reference-Cited by-同舟云学术

Levels of Influenza A Virus Defective Viral Genomes Determine Pathogenesis in the BALB/c Mouse Model

Published:2022-11-09 Issue:21 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Penn Rebecca¹^ORCID,Tregoning John S.¹^ORCID,Flight Katie E.¹,Baillon Laury¹,Frise Rebecca¹,Goldhill Daniel H.¹^ORCID,Johansson Cecilia²^ORCID,Barclay Wendy S.¹^ORCID

Affiliation:

1. Department of Infectious Disease, Imperial College London, London, United Kingdom

2. National Heart and Lung Institute, Imperial College London, London, United Kingdom

Abstract

Mammalian infections with highly pathogenic avian influenza viruses (HPAIVs) cause severe disease associated with excessive proinflammatory cytokine production. Aberrant replication products, such as defective viral genomes (DVGs), can stimulate the antiviral response, and cytokine induction is associated with their emergence in vivo .

Funder

UKRI | Medical Research Council

Coalition for Epidemic Preparedness Innovations

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01178-22

Reference68 articles.

1. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia