Different effects of phytohemagglutinin-activated lymphocytes and their culture supernatants on macrophage function

Author:

Ando M,Suga M,Shima K,Sugimoto M,Higuchi S

Abstract

When rabbit peritoneal exudate cells were incubated for 24 and 48 h with phytohemagglutinin-activated lymphocytes or their culture supernatants, two times as many cells remained adherent to culture slides as in the controls. More spreading cells were found among the adherent cells in the stimulated cultures. Eighty percent of spreading cells that were induced by supernatants were negative or faintly positive for beta-galactosidase. On the other hand, half of the spreading cells induced by activated lymphocytes were positive (1+ to 4+) for beta-lymphocytes and their supernatants. Under similar conditions, unstimulated peritoneal cells showed less marked activation. These findings show that macrophages can appear morphologically activated and yet not be enzymatically activated by lymphokines. Possible mechanisms of direct interaction of activated lymphocytes and macrophages are discussed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference30 articles.

1. Macrophage activation in tuberculin reactions of rabbits with primary BCG infection and reinfection;Ando M.;J. Reticuloendothel. Soc.,1973

2. Macrophage accumulation, division, maturation, and digestive and microbicidal capacities in tuberculous lesions. IV. Macrophage turnover, Iysosomal enzymes, and division in healing lesions;Ando M.;Lab. Invest.,1972

3. Macrophage accumulation, division, maturation, and digestive and microbicidal capacities in tuberculous lesions. II. Rate at which mononuclear cells enter and divide in primary BCG lesions and those of reinfection;Ando M.;J. Immunol.,1972

4. Leukocyte oxidase: defective activity in chronic granulomatous disease;Baehner R. L.;Science,1967

5. Correction of metabolic deficiencies in the leukocytes of patients with chronic granulomatous disease;Baehner R. L.;J. Clin. Invest.,1970

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