Inhibitory Concentrations of Ciprofloxacin Induce an Adaptive Response Promoting the Intracellular Survival of Salmonella enterica Serovar Typhimurium-Reference-Cited by-同舟云学术

Inhibitory Concentrations of Ciprofloxacin Induce an Adaptive Response Promoting the Intracellular Survival of Salmonella enterica Serovar Typhimurium

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Sridhar Sushmita¹²^ORCID,Forrest Sally¹,Pickard Derek¹,Cormie Claire¹,Lees Emily A.³,Thomson Nicholas R.²⁴,Dougan Gordon¹,Baker Stephen¹^ORCID

Affiliation:

1. Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom

2. Wellcome Sanger Institute, Hinxton, United Kingdom

3. Department of Paediatrics, University of Oxford, Oxford, United Kingdom

4. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

Abstract

Antimicrobial resistance is a critical concern in global health. In particular, there is rising resistance to fluoroquinolones, such as ciprofloxacin, a first-line antimicrobial for many Gram-negative pathogens.

Funder

Wellcome

NIHR

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01093-21

Reference65 articles.

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3. The Fluoroquinolones

4. Mechanism of Quinolone Action and Resistance

5. Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

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