Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection-Reference-Cited by-同舟云学术

Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection

Published:2019-08-27 Issue:4 Volume:10 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Scholte Florine E. M.¹^ORCID,Hua Brian L.¹,Spengler Jessica R.¹^ORCID,Dzimianski John V.²,Coleman-McCray JoAnn D.¹,Welch Stephen R.¹^ORCID,McMullan Laura K.¹^ORCID,Nichol Stuart T.¹,Pegan Scott D.²,Spiropoulou Christina F.¹,Bergeron Éric¹^ORCID

Affiliation:

1. Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, USA

Abstract

Crimean-Congo hemorrhagic fever virus is an important human pathogen with a wide global distribution for which no therapeutic interventions are available. CCHFV encodes a cysteine protease belonging to the ovarian tumor (OTU) family which is involved in host immune suppression. Here we demonstrate that artificially prolonged binding of the OTU to a substrate inhibits virus infection. This provides novel insights into CCHFV OTU function during the viral replicative cycle and highlights the OTU as a potential antiviral target.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | Centers for Disease Control and Prevention

American Society for Microbiology

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01065-19

Reference41 articles.

1. Seroepidemiological Studies of Crimean-Congo Hemorrhagic Fever Virus in Domestic and Wild Animals