Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium-Reference-Cited by-同舟云学术

Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Iverson Ethan¹,Griswold Kira¹,Song Daniel²,Gagliardi Talita B.¹,Hamidzadeh Kajal¹,Kesimer Mehmet³,Sinha Sanju⁴⁵,Perry Melissa¹,Duncan Gregg A.²,Scull Margaret A.¹^ORCID

Affiliation:

1. Department of Cell Biology & Molecular Genetics, Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA

2. Fischell Department of Bioengineering, University of Maryland, College Park, Maryland, USA

3. Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA

4. Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

5. Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA

Abstract

Influenza A virus (IAV) targets airway epithelial cells for infection. Large, heavily glycosylated molecules known as tethered mucins extend from the airway epithelial cell surface and may physically restrict pathogen access to underlying cells.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

Burroughs Wellcome Fund

Cystic Fibrosis Foundation

Francis Family Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01055-22