Phylogeny Reveals Novel HipA-Homologous Kinase Families and Toxin-Antitoxin Gene Organizations-Reference-Cited by-同舟云学术

Phylogeny Reveals Novel HipA-Homologous Kinase Families and Toxin-Antitoxin Gene Organizations

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Gerdes Kenn¹,Bærentsen Rene²,Brodersen Ditlev E.²

Affiliation:

1. Centre of Excellence for Bacterial Stress Response and Persistence, Section for Functional Genomics, Department of Biology, University of Copenhagen, Copenhagen N, Denmark

2. Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark

Abstract

Bacterial multidrug tolerance and persistence are problems of increasing scientific and medical significance. The first gene discovered to confer persistence was hipA , encoding the kinase toxin of the hipBA toxin-antitoxin (TA) module of E. coli .

Funder

Danmarks Grundforskningsfond

Novo Nordisk Fonden

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01058-21

Reference89 articles.

1. Mechanisms essential for stable inheritance of mini-F plasmid;Hiraga S;Basic Life Sci,1985

2. Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells.